Fibroblast Growth Factor Receptor-1 (FGFR-1) Is Essential for Normal Neural Tube and Limb Development
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چکیده
منابع مشابه
Fibroblast growth factor receptor-1 is essential for in vitro cardiomyocyte development.
Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling plays a crucial role in mesoderm formation and patterning. Heartless mutant studies in Drosophila suggest that FGFR1, among the different FGFRs, may play a role in cardiogenesis. However, fgfr1-/- mice die during gastrulation before heart formation. To establish the contribution of FGFR1 in cardiac development, we investigated the cap...
متن کاملFibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development.
OBJECTIVE The purpose of this study was to clarify the role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in hematopoietic/endothelial development. METHODS AND RESULTS Using several different FGFR-1-specific antibodies and FGFR-1 promoter-driven LacZ activity, we show that FGFR-1 is expressed and active as a tyrosine kinase in a subpopulation of endothelial cells (approximatel...
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BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...
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background: genetic factors associated with cancer have been widely investigated and several polymorphisms have been connected with breast cancer. breast cancer (bc) can be considered one of the most popular reasons of death among women. bc, likewise, is the second cause of death in iran. the present research aims at determining the frequency of the fibroblast growth factor receptor (fgfr) gene ...
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INTRODUCTION Cartilage degeneration driven by catabolic stimuli is a critical pathophysiological process in osteoarthritis (OA). We have defined fibroblast growth factor 2 (FGF-2) as a degenerative mediator in adult human articular chondrocytes. Biological effects mediated by FGF-2 include inhibition of proteoglycan production, up-regulation of matrix metalloproteinase-13 (MMP-13), and stimulat...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1997
ISSN: 0012-1606
DOI: 10.1006/dbio.1997.8553